Buy SS-31 Peptide in Australia
Buy SS-31 in Australia from Macropus Peptides in two priced vials, 10mg and 50mg. Also known as elamipretide, it is a four amino acid peptide that concentrates at the inner mitochondrial membrane and binds cardiolipin, which makes it a standard tool in research on respiration, membrane potential and oxidative stress. Each vial holds lyophilised research material, sealed and labelled with compound, fill, lot number and storage temperature, and every lot has a certificate of analysis on request. The 10mg vial covers respirometry runs, isolated mitochondria work and cell culture pilots, while the 50mg vial holds five times the peptide for a little over twice the price and suits longer programmes on one batch. Order SS-31 online with bacteriostatic water, add NAD+ or MOTS-C for combined mitochondrial designs, and your parcel is dispatched from our Australian shelves to any Australian address. SS-31 is sold to adults for in-vitro laboratory research only and is not for human or veterinary use.
| Compound | SS-31 |
|---|---|
| Amount | 10 mg |
| Form | Lyophilised powder |
| Category | Longevity and cognitive |
| Storage | -20 °C, protect from light |
| Testing | HPLC purity 98% or higher and mass spectrometry identity, every batch |
| Certificate of analysis | Available for every lot, matched to the lot number on the label |
SS-31 10mg vial
Enter the diluent volume added to this vial to see the solution concentration. Laboratory calculation only, not dosing guidance.
Buy SS-31 Australia: 10mg and 50mg Research Vials
Macropus Peptides supplies this mitochondria-targeted tetrapeptide in two priced fills, 10mg and 50mg, and both go straight into the cart. It is one of the best-characterised peptides in mitochondrial research, and we sell it as lyophilised material for laboratory use. Each vial belongs to a numbered lot backed by its own certificate of analysis, and the two fills differ only in quantity and cost per milligram.
SS-31 Australia: what the peptide is
SS-31 is a synthetic four amino acid peptide with the sequence D-Arg-Dmt-Lys-Phe-NH2, where Dmt stands for 2',6'-dimethyltyrosine and the chain ends in an amide. The D-arginine at the start protects it from enzymes that trim peptides from their ends, and the alternating aromatic and positively charged residues are what let it reach mitochondria. Its molar mass is close to 640 g per mole as the free base, and at neutral pH it carries a net charge of plus three. It comes from a series of small peptides introduced in 2004, in a Journal of Biological Chemistry paper, as antioxidants aimed at mitochondria, and in clinical development it carries the non-proprietary name elamipretide.
How SS-31 works in research
Most molecules aimed at mitochondria are lipophilic cations that are drawn in by the membrane voltage. This peptide behaves differently: it enters cells and gathers at the inner mitochondrial membrane without relying on that voltage. There it binds cardiolipin, a lipid found almost only in that membrane, which holds the respiratory chain complexes and cytochrome c in place. When cardiolipin is oxidised or disordered, cytochrome c drifts away from carrying electrons and electron transport becomes less efficient. Binding to cardiolipin is reported to keep the folded inner membrane, the cristae, intact and to preserve cytochrome c function. Researchers therefore use it to study respiration, membrane potential, reactive oxygen species and cristae structure in isolated mitochondria, cultured cells and animal models. Typical readouts include oxygen consumption on a plate-based respirometer, potential-sensitive fluorescent dyes, electron microscopy of cristae and assays of cytochrome c release.
SS-31 research: what the studies show
The founding 2004 paper examined how the peptides enter mitochondria and measured mitochondrial swelling, oxidative cell death and injury in an isolated heart model after blood flow was interrupted and restored. Kidney ischaemia in rats was the model for a 2013 report in JASN, the American Society of Nephrology journal, which added binding assays to examine its interaction with cardiolipin and cytochrome c. A 2014 review in the British Journal of Pharmacology described the cardiolipin mechanism and summarised preclinical and early clinical evaluation. Elamipretide has since been assessed in clinical trials in inherited mitochondrial disease. Each study is summarised in our SS-31 research studies library.
SS-31 vial specifications
| Specification | Detail |
|---|---|
| Compound | SS-31 |
| Amount | 10 mg |
| Form | Lyophilised powder |
| Category | Longevity and cognitive |
| Storage | -20 °C, protect from light |
Each crimped vial holds the tetrapeptide as a white freeze-dried solid, its label stating name, fill, lot and freezer setting. We pair that lot with its certificate of analysis whenever you ask. Unopened stock belongs in a dark -20 °C freezer. After reconstitution keep the solution cold, at 2 to 8 °C, and avoid freeze and thaw cycles. Being strongly positively charged, it can cling to plastic and glass at very low working concentrations, so final dilutions behave better in low-binding tubes. Synthetic peptides of this kind are usually isolated as a salt, so the certificate is the place to confirm the counter-ion before converting milligrams into moles.
SS-31 price: cost per milligram of the 10mg and 50mg vials
| Strength | Price | Price per mg |
|---|---|---|
| SS-31 10mg | $89.99 | $9.00 per mg |
| SS-31 50mg | $199.99 | $4.00 per mg |
Both mitochondrial peptide vials are sold at a set price in Australian dollars, with nothing quoted or added later. The 50mg fill holds five times the peptide of the 10mg fill for a little over twice the price; per milligram, that is less than half the smaller vial's figure. Once a study will need more than two or three small vials, the larger fill is the cheaper way to keep the whole series on one lot. The SS-31 starter kit bundles the same vial with its consumables for a first order.
SS-31 10mg: the vial to order for mitochondrial work
Most mitochondrial groups work from the 10mg vial. It covers respirometry runs, isolated mitochondria experiments and cell culture pilots on a single lot. A 10mg vial taken up in 2 mL holds 5 mg per mL; taken up in 1 mL it holds 10 mg per mL, useful where a stronger stock suits your working dilutions. At 5 mg per mL, twenty aliquots of 0.1 mL each hold 0.5 mg apiece, a practical way to split one vial across a month of runs without warming the whole stock again. The starter kit pairs it with a 3 mL bacteriostatic water vial, ten half-millilitre syringes and a pack of twenty swabs.
SS-31 50mg: the bulk fill for long programmes
The 50mg vial is designed for extended programmes and studies with several arms that should all draw on one batch. Taken up in 5 mL it holds 10 mg per mL; taken up in 10 mL it holds 5 mg per mL, which mirrors the smaller fill in 2 mL, so dilution plans carry straight across. A 10 mL stock splits into a hundred 0.1 mL aliquots of 0.5mg each; freeze the portions not needed that week rather than keeping the whole volume in the fridge.
Where to buy SS-31 in Australia
- Sold online at macropuspeptides.com in 10mg and 50mg, priced from $89.99
- Every batch HPLC tested to 98% or higher purity, with identity confirmed by mass spectrometry
- A certificate of analysis for every lot, matched to the lot number printed on the label
- Same-day dispatch from Australian stock for orders paid before 2pm AEST on a business day
- Tracked delivery Australia wide: standard in 2 to 5 working days, express in 1 to 2 working days
- Payment by PayID or bank transfer, with your order ID as the reference
How to get SS-31: ordering online
- Put the 10mg or 50mg vial in the cart, or choose the starter kit
- Set a vial count to match your study arms
- Put bacteriostatic water in the cart if required
- Tick the adult research-use box before paying
- Keep the lot reference with your respirometry data and ask for its certificate
SS-31 calculator: bac water and stock strength for 10mg and 50mg
Stock strength for this tetrapeptide is simply its mass over the water added. Taken up in 1 mL, 2 mL or 5 mL, the 10mg fill holds 10, 5 or 2 mg per mL respectively. Taken up in 5 mL or 10 mL, the 50mg fill holds 10 or 5 mg per mL. For molar work, 5 mg per mL of the free base is roughly 7.8 millimolar, so a 1 in 1,000 dilution of that stock lands near 7.8 micromolar and a further 1 in 10 near 780 nanomolar; adjust for the salt form printed on the certificate. Pair the peptide with bacteriostatic water 10mL in one order, or see alternatives in our lab supplies range.
Is SS-31 legal in Australia
Yes, for research. Elamipretide lacks an ARTG listing, and no TGA approval exists for it, so our supply is confined to in-vitro and laboratory work and excludes people and animals. The TGA can amend Poisons Standard scheduling, so check the entry that governs your organisation before you order.
SS-31 for sale Australia wide: mitochondrial orders to every state
We dispatch mitochondrial orders from Australian stock, reaching capital cities and regional centres from Darwin and Hobart to Toowoomba and Albury. For mitochondrial work it is commonly paired with NAD+ and MOTS-C, all three sit together in the longevity stack, and Glutathione adds a thiol redox readout. Other ageing research compounds fill out our longevity and cognitive range.
References
- Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. Journal of Biological Chemistry. 2004.
- The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. Journal of the American Society of Nephrology. 2013.
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. British Journal of Pharmacology. 2014.
Scientific content compiled from the peer-reviewed literature above by the Macropus Peptides technical team. Information is provided for research reference only.